Hybrid SPECT/CT devices, since the first commercial device in 1990 by GE Healthcare, allow combined functional and anatomical assessment. Although planar imaging and SPECT are routinely performed studies, the roles of CT coregistration and specific imaging protocols have yet to be clearly defined. Generally the usage will depend on clinical requirements. Recent studies have evaluated the usage of SPECT/CT hybrid imaging for Tc99m Bone Scans. Tarik Belhocine from South Street Hospital, London, Ontorio, Canada, assessed 51 consecutive patients with suspected bone metastasis. In 82% of the cases, SPECT/CT was useful in improving confidence of interpretation, and in 37% of cases, SPECT/CT was useful for directing further work-up. SPECT/CT was found to be useful in clarifying equivocal findings and directing further appropriate evaluations. A Mount Sinai School of Medicine study in 80 patients found that SPECT/CT was more accurate in predicting the final diagnosis and localizing the lesion as compared with planar scans. Diagnostic confidence in SPECT/CT is significantly higher as compared with normal planar images. SPECT/CT is a promising new modality in the field of functional imaging, and based on initial reports on the use with bone scans, it may prove to supplement existing protocols for patient referrals. (Sports Medicine Association Singapore 01/2009)